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Browse Drug List


Drugs That Prolong the Q-T Interval and/or Induce Torsades de Pointes
Raymond L. Woosley, MD, PhD

Information from the medical literature, the FDA-approved drug labeling and reports submitted to the FDA Adverse Events Reporting System database.

  Browse by clicking on the first letter of the drug's brand or generic name:

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Generic Name Domperidone* More Info
Brand Name(s) Motilium®
Drug Class Anti-nausea
QT
TdP
Risk Group A drug that is generally accepted by authorities to have a risk of causing Torsades de Pointes. This drug should be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

not available in the United States
   
   



Generic Name Isoproterenol More Info
Brand Name(s) Isupres®,Medihaler-Iso®
Drug Class Catecholamine
QT
TdP
Risk Group A drug to be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Mesoridazine More Info
Brand Name(s) Serentil®
Drug Class Anti-psychotic
QT
QT prolongation is mentioned in the FDA-approved labeling as a known action of the drug.
TdP
The FDA-approved labeling includes mention of cases or a risk of Torsades de Pointes.
Risk Group A drug that is generally accepted by authorities to have a risk of causing Torsades de Pointes. This drug should be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Metaproterenol More Info
Brand Name(s) Alupent®,Metaprel®
Drug Class Bronchodilator
QT
TdP
Risk Group A drug to be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Methadone More Info
Brand Name(s) Dolophine®,Methadose®
Drug Class Opiate agonist
QT
TdP
Risk Group A drug that is generally accepted by authorities to have a risk of causing Torsades de Pointes. This drug should be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

Females>Males
   
   



Generic Name Methylphenidate More Info
Brand Name(s) Concerta® ,Ritalin®
Drug Class CNS stimulant
QT
TdP
Risk Group A drug to be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Mexiletine More Info
Brand Name(s) Mexitil®
Drug Class Anti-arrhythmic
QT
TdP
Risk Group A drug that, in some reports, has been weakly associated with Torsades de Pointes but that, when used in usual dosages, is unlikely to be a risk for Torsades de Pointes.
Comments

   
   



Generic Name Midodrine More Info
Brand Name(s) ProAmatine®
Drug Class Vasoconstrictor
QT
TdP
Risk Group A drug to be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Moexipril/HCTZ More Info
Brand Name(s) Uniretic®
Drug Class Anti-hypertensive
QT
QT prolongation is mentioned in the FDA-approved labeling as a known action of the drug.
TdP
Risk Group A drug that may prolong the QT interval but at this time lacks substantial evidence for causing Torsades de Pointes. This drug should be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Moxifloxacin More Info
Brand Name(s) Avelox®
Drug Class Antibiotic
QT
QT prolongation is mentioned in the FDA-approved labeling as a known action of the drug.
TdP
Risk Group A drug that may prolong the QT interval but at this time lacks substantial evidence for causing Torsades de Pointes. This drug should be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Sibutramine More Info
Brand Name(s) Meridia®
Drug Class Appetitie suppressant
QT
TdP
Risk Group A drug to be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Thioridazine More Info
Brand Name(s) Mellaril®
Drug Class Anti-psychotic
QT
QT prolongation is mentioned in the FDA-approved labeling as a known action of the drug.
TdP
The FDA-approved labeling includes mention of cases or a risk of Torsades de Pointes.
Risk Group A drug that is generally accepted by authorities to have a risk of causing Torsades de Pointes. This drug should be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



  A note about Brand Names: Drugs are listed with up to 2 common brand names. There are many more brand names for some of the common drugs, such as pseudoephedrine and erythromycin. It is also important to look at the list of active drugs in medicines that contain a combination of drugs such as Zyrtec-D®, which contains pseudoephedrine.
 
 

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Funded in part by Agency for Healthcare Research and Quality grant 1 U18 HS10385-01

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