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Browse Drug List


Drugs That Prolong the Q-T Interval and/or Induce Torsades de Pointes
Raymond L. Woosley, MD, PhD

Information from the medical literature, the FDA-approved drug labeling and reports submitted to the FDA Adverse Events Reporting System database.

  Browse by clicking on the first letter of the drug's brand or generic name:

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Generic Name Albuterol More Info
Brand Name(s) Proventil®,Ventolin®
Drug Class Bronchodilator
QT
TdP
Risk Group A drug to be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Amiodarone More Info
Brand Name(s) Cordarone®,Pacerone®
Drug Class Anti-arrhythmic
QT
QT prolongation is mentioned in the FDA-approved labeling as a known action of the drug.
TdP
The FDA-approved labeling includes mention of cases or a risk of Torsades de Pointes.
Risk Group A drug that is generally accepted by authorities to have a risk of causing Torsades de Pointes. This drug should be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments
There are case reports of Torsades de Pointes in the medical literature.
Females>Males,TdP risk regarded as low
   
   



Generic Name Cisapride More Info
Brand Name(s) Propulsid®
Drug Class GI stimulant
QT
QT prolongation is mentioned in the FDA-approved labeling as a known action of the drug.
TdP
The FDA-approved labeling includes mention of cases or a risk of Torsades de Pointes.
Risk Group A drug that is generally accepted by authorities to have a risk of causing Torsades de Pointes. This drug should be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments
Substantial evidence indicates a greater risk of Torsades de Pointes in women.
Restricted availability; Females>Males.
   
   



Generic Name Desipramine More Info
Brand Name(s) Pertofrane®
Drug Class Tricyclic Antidepressant
QT
TdP
Risk Group A drug that, in some reports, has been weakly associated with Torsades de Pointes but that, when used in usual dosages, is unlikely to be a risk for Torsades de Pointes.
Comments

   
   



Generic Name Epinephrine More Info
Brand Name(s) Bronkaid®,Primatene®
Drug Class catecholamine, vasoconstrictor
QT
TdP
Risk Group A drug to be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Fenfluramine More Info
Brand Name(s) Pondimin®
Drug Class Appetite suppressant
QT
TdP
Risk Group A drug to be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Fluoxetine More Info
Brand Name(s) Prozac®,Sarafem®
Drug Class Anti-depressant
QT
QT prolongation is mentioned in the FDA-approved labeling as a known action of the drug.
TdP
The FDA-approved labeling includes mention of cases or a risk of Torsades de Pointes.
Risk Group A drug that, in some reports, has been weakly associated with Torsades de Pointes but that, when used in usual dosages, is unlikely to be a risk for Torsades de Pointes.
Comments
Association not clear
   
   



Generic Name Midodrine More Info
Brand Name(s) ProAmatine®
Drug Class Vasoconstrictor
QT
TdP
Risk Group A drug to be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Nortriptyline More Info
Brand Name(s) Pamelor®
Drug Class Tricyclic Antidepressant
QT
TdP
Risk Group A drug that, in some reports, has been weakly associated with Torsades de Pointes but that, when used in usual dosages, is unlikely to be a risk for Torsades de Pointes.
Comments

   
   



Generic Name Paroxetine More Info
Brand Name(s) Paxil®
Drug Class Anti-depressant
QT
TdP
The FDA-approved labeling includes mention of cases or a risk of Torsades de Pointes.
Risk Group A drug that, in some reports, has been weakly associated with Torsades de Pointes but that, when used in usual dosages, is unlikely to be a risk for Torsades de Pointes.
Comments

   
   



Generic Name Pentamidine More Info
Brand Name(s) NebuPent®,Pentam®
Drug Class Anti-infective
QT
QT prolongation is mentioned in the FDA-approved labeling as a known action of the drug.
TdP
The FDA-approved labeling includes mention of cases or a risk of Torsades de Pointes.
Risk Group A drug that is generally accepted by authorities to have a risk of causing Torsades de Pointes. This drug should be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments
Substantial evidence indicates a greater risk of Torsades de Pointes in women.
Females>Males
   
   



Generic Name Phentermine More Info
Brand Name(s) Adipex®,Fastin®
Drug Class Appetite suppressant
QT
TdP
Risk Group A drug to be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Phenylephrine More Info
Brand Name(s) Neosynephrine®
Drug Class Vasoconstrictor, decongestant
QT
TdP
Risk Group A drug to be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Phenylpropanolamine More Info
Brand Name(s) Acutrim®,Dexatrim®
Drug Class Decongestant
QT
TdP
Risk Group A drug to be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Pimozide More Info
Brand Name(s) Orap®
Drug Class Anti-psychotic
QT
QT prolongation is mentioned in the FDA-approved labeling as a known action of the drug.
TdP
Risk Group A drug that is generally accepted by authorities to have a risk of causing Torsades de Pointes. This drug should be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments
Substantial evidence indicates a greater risk of Torsades de Pointes in women. There are case reports of Torsades de Pointes in the medical literature.
Females>Males
   
   



Generic Name Procainamide More Info
Brand Name(s) Procan® ,Pronestyl®
Drug Class Anti-arrhythmic
QT
QT prolongation is mentioned in the FDA-approved labeling as a known action of the drug.
TdP
The FDA-approved labeling includes mention of cases or a risk of Torsades de Pointes.
Risk Group A drug that is generally accepted by authorities to have a risk of causing Torsades de Pointes. This drug should be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Protriptyline More Info
Brand Name(s) Vivactil®
Drug Class Tricyclic Antidepressant
QT
TdP
Risk Group A drug that, in some reports, has been weakly associated with Torsades de Pointes but that, when used in usual dosages, is unlikely to be a risk for Torsades de Pointes.
Comments

   
   



Generic Name Pseudoephedrine More Info
Brand Name(s) PediaCare®,Sudafed®
Drug Class Decongestant
QT
TdP
Risk Group A drug to be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

   
   



Generic Name Tacrolimus More Info
Brand Name(s) Prograf®
Drug Class Immunosuppressant
QT
TdP
Risk Group A drug that may prolong the QT interval but at this time lacks substantial evidence for causing Torsades de Pointes. This drug should be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments
There are case reports of Torsades de Pointes in the medical literature.
   
   



  A note about Brand Names: Drugs are listed with up to 2 common brand names. There are many more brand names for some of the common drugs, such as pseudoephedrine and erythromycin. It is also important to look at the list of active drugs in medicines that contain a combination of drugs such as Zyrtec-D®, which contains pseudoephedrine.
 
 

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