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Drug Lists (by Risk Groups)

Drugs that Prolong the Qt Interval and/or Induce Torsades de Pointes Ventricular Arrhythmia

Drug-induced ventricular tachycardia associated with prolongation of the QT interval is a well-recognized form of drug toxicity termed Torsades de Pointes (TdP). Because the evidence for risk is variable between the many drugs associated with TdP, we have divided the drugs into four groups. Each of the following four lists of drugs relate to their relative risk of inducing Torsades de Pointes or prolonged QT. To construct these lists, AZCERT only surveys drugs marketed in the United States (US). However, some drugs marketed in countries other than the US come to our attention and are included. Those drugs are designated with an asterisk.

  Drugs that are generally accepted by the Scientific Advisory Board of the AZCERT to have a risk of causing Torsades de Pointes.
  Drugs that in some reports have been associated with Torsades de Pointes and/or QT prolongation but at this time lack substantial evidence for causing Torsades de Pointes.
View Drug List 3
  Drugs to be avoided for use in patients with diagnosed or suspected congenital long QT syndrome. (Drugs on Lists 1, 2, and 4 are also included here.)
  Drugs that, in some reports, have been weakly associated with Torsades de Pointes and/or QT prolongation but that are unlikely to be a risk for Torsades de Pointes when used in usual recommended dosages and in patients without other risk factors (e.g., concomitant QT prolonging drugs, bradycardia, electrolyte disturbances, congenital long QT syndrome, concomitant drugs that inhibit metabolism).

A few notes about the Lists:
Drugs are listed with up to 2 common brand names.
There are many more brand names for some of the common drugs, such as pseudoephedrine and erythromycin. It is also important to look at the list of active drugs in medicines that contain a combination of drugs such as Zyrtec-D®, which contains pseudoephedrine.

Each list includes electronic links to PubMed literature searches so that a comprehensive list of references to current medical literature can be conveniently accessed. The lists are formatted to be viewed online or for printing.

The University of Arizona Center for Education and Research on Therapeutics
Arizona Health Sciences Center
Tucson, Arizona 85724-5018

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