Drugs that are generally accepted by the QTdrugs.org Advisory Board of the Arizona CERT to have a risk of causing torsades de pointes.
 
 
Amiodarone Cordarone® Anti-arrhythmic / abnormal heart rhythm Females>Males,TdP risk regarded as low
Amiodarone Pacerone® Anti-arrhythmic / abnormal heart rhythm Females>Males,TdP risk regarded as low
Arsenic trioxide Trisenox® Anti-cancer / Leukemia
Bepridil Vascor® Anti-anginal / heart pain Females>Males
Chloroquine Arelan® Anti-malarial / malaria infection
Chlorpromazine Thorazine® Anti-psychotic/ Anti-emetic / schizophrenia/ nausea
Cisapride Propulsid® GI stimulant / heartburn Restricted availability; Females>Males.
Clarithromycin Biaxin® Antibiotic / bacterial infection
Disopyramide Norpace® Anti-arrhythmic / abnormal heart rhythm Females>Males
Dofetilide Tikosyn® Anti-arrhythmic / abnormal heart rhythm
Domperidone* Motilium® Anti-nausea / nausea not available in the United States
Droperidol Inapsine® Sedative;Anti-nausea / anesthesia adjunct, nausea
Erythromycin Erythrocin® Antibiotic;GI stimulant / bacterial infection; increase GI motility Females>Males
Erythromycin E.E.S.® Antibiotic;GI stimulant / bacterial infection; increase GI motility Females>Males
Halofantrine Halfan® Anti-malarial / malaria infection Females>Males
Haloperidol Haldol® Anti-psychotic / schizophrenia, agitation
Ibutilide Corvert® Anti-arrhythmic / abnormal heart rhythm Females>Males
Levomethadyl Orlaam® Opiate agonist / pain control, narcotic dependence
Mesoridazine Serentil® Anti-psychotic / schizophrenia
Methadone Methadose® Opiate agonist / pain control, narcotic dependence Females>Males
Methadone Dolophine® Opiate agonist / pain control, narcotic dependence Females>Males
Pentamidine NebuPent® Anti-infective / pneumocystis pneumonia Females>Males
Pentamidine Pentam® Anti-infective / pneumocystis pneumonia Females>Males
Pimozide Orap® Anti-psychotic / Tourette's tics Females>Males
Procainamide Pronestyl® Anti-arrhythmic / abnormal heart rhythm
Procainamide Procan® Anti-arrhythmic / abnormal heart rhythm
Quinidine Quinaglute® Anti-arrhythmic / abnormal heart rhythm Females>Males
Quinidine Cardioquin® Anti-arrhythmic / abnormal heart rhythm Females>Males
Sotalol Betapace® Anti-arrhythmic / abnormal heart rhythm Females>Males
Sparfloxacin Zagam® Antibiotic / bacterial infection
Thioridazine Mellaril® Anti-psychotic / schizophrenia
 
 
Revised: 03/01/2006


Source: www.QTdrugs.org

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Drugs on the QT Drug Lists are reviewed on an ongoing basis to assure the evidence is still appropriate for their placement on their respective list.


   
KEY
Females>Males:
Substantial evidence indicates a greater risk
(usually > two-fold) of TdP in women
   

Arizona Center for Education and Research on Therapeutics
The Critical Path Institute

Tucson, Arizona and Rockville, Maryland

Funded in part by Agency for Healthcare Research and Quality grant 1 U18 HS10385

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