Drugs that in some reports have been associated with torsades de pointes and/or QT prolongation but at this time lack substantial evidence for causing torsades de pointes.
Alfuzosin Uroxatral® Alpha1-blocker / Benign prostatic hyperplasia
Amantadine Symmetrel® Dopaminergic/Anti-viral / Anti-infective/ Parkinson's Disease
Azithromycin Zithromax® Antibiotic / bacterial infection
Chloral hydrate Noctec® Sedative / sedation/ insomnia
Clozapine Clozaril® Anti-psychotic / schizophrenia
Dolasetron Anzemet® Anti-nausea / nausea, vomiting
Felbamate Felbatrol® Anti-convulsant / seizure
Flecainide Tambocor® Anti-arrhythmic / abnormal heart rhythm
Foscarnet Foscavir® Anti-viral / HIV infection
Fosphenytoin Cerebyx® Anti-convulsant / seizure
Gatifloxacin Tequin® Antibiotic / bacterial infection
Gemifloxacin Factive® Antibiotic / bacterial infection
Granisetron Kytril® Anti-nausea / nausea and vomiting
Indapamide Lozol® Diuretic / stimulate urine & salt loss
Isradipine Dynacirc® Anti-hypertensive / high blood pressure
Levofloxacin Levaquin® Antibiotic / bacterial infection
Lithium Lithobid® Anti-mania / bipolar disorder
Lithium Eskalith® Anti-mania / bipolar disorder
Moexipril/HCTZ Uniretic® Anti-hypertensive / high blood pressure
Moxifloxacin Avelox® Antibiotic / bacterial infection
Nicardipine Cardene® Anti-hypertensive / high blood pressure
Octreotide Sandostatin® Endocrine / acromegaly, carcinoid diarrhea
Ofloxacin Floxin® Antibiotic / bacterial infection
Ondansetron Zofran® Anti-emetic / nausea and vomiting
Quetiapine Seroquel® Anti-psychotic / schizophrenia
Ranolazine Ranexa® Anti-anginal / chronic angina
Risperidone Risperdal® Anti-psychotic / schizophrenia
Roxithromycin* Rulide® Antibiotic / bacterial infection *not available in the United States
Tacrolimus Prograf® Immunosuppressant / Immune suppression
Tamoxifen Nolvadex® Anti-cancer / breast cancer
Telithromycin Ketek® Antibiotic / bacterial infection
Tizanidine Zanaflex® Muscle relaxant /
Vardenafil Levitra® phosphodiesterase inhibitor / vasodilator
Venlafaxine Effexor® Anti-depressant / depression
Voriconazole VFend® Anti-fungal / anti-fungal
Ziprasidone Geodon® Anti-psychotic / schizophrenia
Revised: 03/01/2006

Source: www.QTdrugs.org

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Drugs on the QT Drug Lists are reviewed on an ongoing basis to assure the evidence is still appropriate for their placement on their respective list.


Arizona Center for Education and Research on Therapeutics
The Critical Path Institute

Tucson, Arizona and Rockville, Maryland

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