Drugs to be avoided for use in patients with diagnosed or suspected congenital long QT syndrome. (Drugs on Lists 1, 2, and 4 are also included here.)

 
 
Phenylpropanolamine Acutrim® Decongestant / allergies, sinusitis, asthma 3
Amphetamine Adderall® CNS stimulant / ADHD This includes dextroamphetamine and amphetamine / dextroamphetamine combinations. 3
Phentermine Adipex® Appetite suppressant / dieting, weight loss 3
Metaproterenol Alupent® Bronchodilator / asthma 3
Clomipramine Anafranil® Tricyclic Antidepressant / depression 4
Dolasetron Anzemet® Anti-nausea / nausea, vomiting 2
Chloroquine Arelan® Anti-malarial / malaria infection 1
Amoxapine Asendin® Tricyclic Antidepressant / depression 4
Moxifloxacin Avelox® Antibiotic / bacterial infection 2
Trimethoprim-Sulfa Bactrim® Antibiotic / bacterial infection 4
Sotalol Betapace® Anti-arrhythmic / abnormal heart rhythm Females>Males 1
Clarithromycin Biaxin® Antibiotic / bacterial infection 1
Terbutaline Brethine® Bronchodilator / asthma 3
Ephedrine Broncholate® Bronchodilator, decongestant / Allergies, sinusitis, asthma 3
Epinephrine Bronkaid® catecholamine, vasoconstrictor / anaphylaxis, allergic reactions 3
Nicardipine Cardene® Anti-hypertensive / high blood pressure 2
Quinidine Cardioquin® Anti-arrhythmic / abnormal heart rhythm Females>Males 1
Citalopram Celexa® Anti-depressant / depression 4
Fosphenytoin Cerebyx® Anti-convulsant / seizure 2
Ciprofloxacin Cipro® Antibiotic / bacterial infection 4
Clozapine Clozaril® Anti-psychotic / schizophrenia 2
Cocaine Cocaine Local anesthetic / 3
Methylphenidate Concerta® CNS stimulant / ADHD 3
Amiodarone Cordarone® Anti-arrhythmic / abnormal heart rhythm Females>Males,TdP risk regarded as low 1
Ibutilide Corvert® Anti-arrhythmic / abnormal heart rhythm Females>Males 1
Tolterodine Detrol LA® Bladder Antispasmodic / 3
Tolterodine Detrol® Bladder Antispasmodic / 3
Amphetamine Dexadrine® CNS stimulant / ADHD This includes dextroamphetamine and amphetamine / dextroamphetamine combinations. 3
Phenylpropanolamine Dexatrim® Decongestant / allergies, sinusitis, asthma 3
Fluconazole Diflucan® Anti-fungal / fungal infection 4
Dobutamine Dobutrex® Catecholamine / heart failure and shock 3
Methadone Dolophine® Opiate agonist / pain control, narcotic dependence Females>Males 1
Isradipine Dynacirc® Anti-hypertensive / high blood pressure 2
Erythromycin E.E.S.® Antibiotic;GI stimulant / bacterial infection; increase GI motility Females>Males 1
Venlafaxine Effexor® Anti-depressant / depression 2
Amitriptyline Elavil® Tricyclic Antidepressant / depression 4
Erythromycin Erythrocin® Antibiotic;GI stimulant / bacterial infection; increase GI motility Females>Males 1
Lithium Eskalith® Anti-mania / bipolar disorder 2
Gemifloxacin Factive® Antibiotic / bacterial infection 2
Phentermine Fastin® Appetite suppressant / dieting, weight loss 3
Felbamate Felbatrol® Anti-convulsant / seizure 2
Ofloxacin Floxin® Antibiotic / bacterial infection 2
Dexmethylphenidate Focalin® CNS stimulant / ADHD 3
Foscarnet Foscavir® Anti-viral / HIV infection 2
Ziprasidone Geodon® Anti-psychotic / schizophrenia 2
Haloperidol Haldol® Anti-psychotic / schizophrenia, agitation 1
Halofantrine Halfan® Anti-malarial / malaria infection Females>Males 1
Droperidol Inapsine® Sedative;Anti-nausea / anesthesia adjunct, nausea 1
Dopamine Intropine® Anti-arrhythmic / abnormal heart rhythm 3
Isoproterenol Isupres® Catecholamine / allergic reaction 3
Telithromycin Ketek® Antibiotic / bacterial infection 2
Granisetron Kytril® Anti-nausea / nausea and vomiting 2
Levofloxacin Levaquin® Antibiotic / bacterial infection 2
Vardenafil Levitra® phosphodiesterase inhibitor / vasodilator 2
Norepinephrine Levophed® Vasconstrictor, Inotrope / shock, low blood pressure 3
Lithium Lithobid® Anti-mania / bipolar disorder 2
Indapamide Lozol® Diuretic / stimulate urine & salt loss 2
Isoproterenol Medihaler-Iso® Catecholamine / allergic reaction 3
Thioridazine Mellaril® Anti-psychotic / schizophrenia 1
Sibutramine Meridia® Appetitie suppressant / dieting, weight loss 3
Metaproterenol Metaprel® Bronchodilator / asthma 3
Methadone Methadose® Opiate agonist / pain control, narcotic dependence Females>Males 1
Mexiletine Mexitil® Anti-arrhythmic / Abnormal heart rhythm 4
Domperidone* Motilium® Anti-nausea / nausea not available in the United States 1
Pentamidine NebuPent® Anti-infective / pneumocystis pneumonia Females>Males 1
Phenylephrine Neosynephrine® Vasoconstrictor, decongestant / low blood pressure, allergies, sinusitis, asthma 3
Ketoconazole Nizoral® Anti-fungal / fungal infection 4
Chloral hydrate Noctec® Sedative / sedation/ insomnia 2
Tamoxifen Nolvadex® Anti-cancer / breast cancer 2
Imipramine Norfranil® Tricyclic Antidepressant / depression 4
Disopyramide Norpace® Anti-arrhythmic / abnormal heart rhythm Females>Males 1
Pimozide Orap® Anti-psychotic / Tourette's tics Females>Males 1
Levomethadyl Orlaam® Opiate agonist / pain control, narcotic dependence 1
Amiodarone Pacerone® Anti-arrhythmic / abnormal heart rhythm Females>Males,TdP risk regarded as low 1
Nortriptyline Pamelor® Tricyclic Antidepressant / depression 4
Paroxetine Paxil® Anti-depressant / depression 4
Pseudoephedrine PediaCare® Decongestant / allergies, sinusitis, asthma 3
Pentamidine Pentam® Anti-infective / pneumocystis pneumonia Females>Males 1
Desipramine Pertofrane® Tricyclic Antidepressant / depression 4
Fenfluramine Pondimin® Appetite suppressant / dieting, weight loss 3
Epinephrine Primatene® catecholamine, vasoconstrictor / anaphylaxis, allergic reactions 3
Midodrine ProAmatine® Vasoconstrictor / low blood pressure, fainting 3
Procainamide Procan® Anti-arrhythmic / abnormal heart rhythm 1
Tacrolimus Prograf® Immunosuppressant / Immune suppression 2
Procainamide Pronestyl® Anti-arrhythmic / abnormal heart rhythm 1
Cisapride Propulsid® GI stimulant / heartburn Restricted availability; Females>Males. 1
Albuterol Proventil® Bronchodilator / Asthma 3
Fluoxetine Prozac® Anti-depressant / depression 4
Quinidine Quinaglute® Anti-arrhythmic / abnormal heart rhythm Females>Males 1
Ranolazine Ranexa® Anti-anginal / chronic angina 2
Galantamine Reminyl® Cholinesterase inhibitor / Dementia, Alzheimer's 4
Risperidone Risperdal® Anti-psychotic / schizophrenia 2
Methylphenidate Ritalin® CNS stimulant / ADHD 3
Roxithromycin* Rulide® Antibiotic / bacterial infection *not available in the United States 2
Ephedrine Rynatuss® Bronchodilator, decongestant / Allergies, sinusitis, asthma 3
Octreotide Sandostatin® Endocrine / acromegaly, carcinoid diarrhea 2
Fluoxetine Sarafem® Anti-depressant / depression 4
Mesoridazine Serentil® Anti-psychotic / schizophrenia 1
Salmeterol Serevent® Sympathomimetic / asthma, COPD 3
Quetiapine Seroquel® Anti-psychotic / schizophrenia 2
Doxepin Sinequan® Tricyclic Antidepressant / depression 4
Itraconazole Sporanox® Anti-fungal / fungal infection 4
Atomoxetine Strattera® norepinephrine reuptake inhibitor / ADHD 3
Pseudoephedrine Sudafed® Decongestant / allergies, sinusitis, asthma 3
Trimethoprim-Sulfa Sulfa® Antibiotic / bacterial infection 4
Trimipramine Surmontil® Tricyclic Antidepressant / depression 4
Amantadine Symmetrel® Dopaminergic/Anti-viral / Anti-infective/ Parkinson's Disease 2
Flecainide Tambocor® Anti-arrhythmic / abnormal heart rhythm 2
Gatifloxacin Tequin® Antibiotic / bacterial infection 2
Chlorpromazine Thorazine® Anti-psychotic/ Anti-emetic / schizophrenia/ nausea 1
Dofetilide Tikosyn® Anti-arrhythmic / abnormal heart rhythm 1
Arsenic trioxide Trisenox® Anti-cancer / Leukemia 1
Moexipril/HCTZ Uniretic® Anti-hypertensive / high blood pressure 2
Alfuzosin Uroxatral® Alpha1-blocker / Benign prostatic hyperplasia 2
Bepridil Vascor® Anti-anginal / heart pain Females>Males 1
Albuterol Ventolin® Bronchodilator / Asthma 3
Solifenacin VESIcare® muscarinic receptor anatagonist / treatment of overactive bladder 4
Voriconazole VFend® Anti-fungal / anti-fungal 2
Protriptyline Vivactil® Tricyclic Antidepressant / depression 4
Levalbuterol Xopenex® Bronchodilator / asthma 3
Ritodrine Yutopar® Uterine relaxant / prevent premature labor 3
Sparfloxacin Zagam® Antibiotic / bacterial infection 1
Tizanidine Zanaflex® Muscle relaxant / 2
Azithromycin Zithromax® Antibiotic / bacterial infection 2
Ondansetron Zofran® Anti-emetic / nausea and vomiting 2
Sertraline Zoloft® Anti-depressant / depression 4
 
 

Revised: 03/01/2006


Source: www.QTdrugs.org

Drugs on the QT Drug Lists are reviewed on an ongoing basis to assure the evidence is still appropriate for their placement on their respective list. 

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KEY
Drug List 1:
Drugs that are generally accepted by authorities to have a risk of causing torsades de pointes.
Drug List 2:
Drugs that may prolong the QT interval but at this time lack substantial evidence for causing torsades de pointes.
Drug List 3:
Drugs to be avoided for use in patients with diagnosed or suspected congenital long QT syndrome. (Drugs on Lists 1 and 2 are also included here.)
Females>Males:
Substantial evidence indicates a greater risk
(usually > two-fold) of TdP in women.

Arizona Center for Education and Research on Therapeutics
The Critical Path Institute

Tucson, Arizona and Rockville, Maryland

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Risk Group 2 Risk Group 4 Risk Group 1