Drugs to be avoided for use in patients with diagnosed or suspected congenital long QT syndrome. (Drugs on Lists 1, 2, and 4 are also included here.)

 
 
Albuterol Ventolin® Bronchodilator / Asthma 3
Albuterol Proventil® Bronchodilator / Asthma 3
Alfuzosin Uroxatral® Alpha1-blocker / Benign prostatic hyperplasia 2
Amantadine Symmetrel® Dopaminergic/Anti-viral / Anti-infective/ Parkinson's Disease 2
Amiodarone Cordarone® Anti-arrhythmic / abnormal heart rhythm Females>Males,TdP risk regarded as low 1
Amiodarone Pacerone® Anti-arrhythmic / abnormal heart rhythm Females>Males,TdP risk regarded as low 1
Amitriptyline Elavil® Tricyclic Antidepressant / depression 4
Amoxapine Asendin® Tricyclic Antidepressant / depression 4
Amphetamine Adderall® CNS stimulant / ADHD This includes dextroamphetamine and amphetamine / dextroamphetamine combinations. 3
Amphetamine Dexadrine® CNS stimulant / ADHD This includes dextroamphetamine and amphetamine / dextroamphetamine combinations. 3
Arsenic trioxide Trisenox® Anti-cancer / Leukemia 1
Atomoxetine Strattera® norepinephrine reuptake inhibitor / ADHD 3
Azithromycin Zithromax® Antibiotic / bacterial infection 2
Bepridil Vascor® Anti-anginal / heart pain Females>Males 1
Chloral hydrate Noctec® Sedative / sedation/ insomnia 2
Chloroquine Arelan® Anti-malarial / malaria infection 1
Chlorpromazine Thorazine® Anti-psychotic/ Anti-emetic / schizophrenia/ nausea 1
Ciprofloxacin Cipro® Antibiotic / bacterial infection 4
Cisapride Propulsid® GI stimulant / heartburn Restricted availability; Females>Males. 1
Citalopram Celexa® Anti-depressant / depression 4
Clarithromycin Biaxin® Antibiotic / bacterial infection 1
Clomipramine Anafranil® Tricyclic Antidepressant / depression 4
Clozapine Clozaril® Anti-psychotic / schizophrenia 2
Cocaine Cocaine Local anesthetic / 3
Desipramine Pertofrane® Tricyclic Antidepressant / depression 4
Dexmethylphenidate Focalin® CNS stimulant / ADHD 3
Disopyramide Norpace® Anti-arrhythmic / abnormal heart rhythm Females>Males 1
Dobutamine Dobutrex® Catecholamine / heart failure and shock 3
Dofetilide Tikosyn® Anti-arrhythmic / abnormal heart rhythm 1
Dolasetron Anzemet® Anti-nausea / nausea, vomiting 2
Domperidone* Motilium® Anti-nausea / nausea not available in the United States 1
Dopamine Intropine® Anti-arrhythmic / abnormal heart rhythm 3
Doxepin Sinequan® Tricyclic Antidepressant / depression 4
Droperidol Inapsine® Sedative;Anti-nausea / anesthesia adjunct, nausea 1
Ephedrine Broncholate® Bronchodilator, decongestant / Allergies, sinusitis, asthma 3
Ephedrine Rynatuss® Bronchodilator, decongestant / Allergies, sinusitis, asthma 3
Epinephrine Bronkaid® catecholamine, vasoconstrictor / anaphylaxis, allergic reactions 3
Epinephrine Primatene® catecholamine, vasoconstrictor / anaphylaxis, allergic reactions 3
Erythromycin Erythrocin® Antibiotic;GI stimulant / bacterial infection; increase GI motility Females>Males 1
Erythromycin E.E.S.® Antibiotic;GI stimulant / bacterial infection; increase GI motility Females>Males 1
Felbamate Felbatrol® Anti-convulsant / seizure 2
Fenfluramine Pondimin® Appetite suppressant / dieting, weight loss 3
Flecainide Tambocor® Anti-arrhythmic / abnormal heart rhythm 2
Fluconazole Diflucan® Anti-fungal / fungal infection 4
Fluoxetine Prozac® Anti-depressant / depression 4
Fluoxetine Sarafem® Anti-depressant / depression 4
Foscarnet Foscavir® Anti-viral / HIV infection 2
Fosphenytoin Cerebyx® Anti-convulsant / seizure 2
Galantamine Reminyl® Cholinesterase inhibitor / Dementia, Alzheimer's 4
Gatifloxacin Tequin® Antibiotic / bacterial infection 2
Gemifloxacin Factive® Antibiotic / bacterial infection 2
Granisetron Kytril® Anti-nausea / nausea and vomiting 2
Halofantrine Halfan® Anti-malarial / malaria infection Females>Males 1
Haloperidol Haldol® Anti-psychotic / schizophrenia, agitation 1
Ibutilide Corvert® Anti-arrhythmic / abnormal heart rhythm Females>Males 1
Imipramine Norfranil® Tricyclic Antidepressant / depression 4
Indapamide Lozol® Diuretic / stimulate urine & salt loss 2
Isoproterenol Isupres® Catecholamine / allergic reaction 3
Isoproterenol Medihaler-Iso® Catecholamine / allergic reaction 3
Isradipine Dynacirc® Anti-hypertensive / high blood pressure 2
Itraconazole Sporanox® Anti-fungal / fungal infection 4
Ketoconazole Nizoral® Anti-fungal / fungal infection 4
Levalbuterol Xopenex® Bronchodilator / asthma 3
Levofloxacin Levaquin® Antibiotic / bacterial infection 2
Levomethadyl Orlaam® Opiate agonist / pain control, narcotic dependence 1
Lithium Eskalith® Anti-mania / bipolar disorder 2
Lithium Lithobid® Anti-mania / bipolar disorder 2
Mesoridazine Serentil® Anti-psychotic / schizophrenia 1
Metaproterenol Alupent® Bronchodilator / asthma 3
Metaproterenol Metaprel® Bronchodilator / asthma 3
Methadone Dolophine® Opiate agonist / pain control, narcotic dependence Females>Males 1
Methadone Methadose® Opiate agonist / pain control, narcotic dependence Females>Males 1
Methylphenidate Ritalin® CNS stimulant / ADHD 3
Methylphenidate Concerta® CNS stimulant / ADHD 3
Mexiletine Mexitil® Anti-arrhythmic / Abnormal heart rhythm 4
Midodrine ProAmatine® Vasoconstrictor / low blood pressure, fainting 3
Moexipril/HCTZ Uniretic® Anti-hypertensive / high blood pressure 2
Moxifloxacin Avelox® Antibiotic / bacterial infection 2
Nicardipine Cardene® Anti-hypertensive / high blood pressure 2
Norepinephrine Levophed® Vasconstrictor, Inotrope / shock, low blood pressure 3
Nortriptyline Pamelor® Tricyclic Antidepressant / depression 4
Octreotide Sandostatin® Endocrine / acromegaly, carcinoid diarrhea 2
Ofloxacin Floxin® Antibiotic / bacterial infection 2
Ondansetron Zofran® Anti-emetic / nausea and vomiting 2
Paroxetine Paxil® Anti-depressant / depression 4
Pentamidine NebuPent® Anti-infective / pneumocystis pneumonia Females>Males 1
Pentamidine Pentam® Anti-infective / pneumocystis pneumonia Females>Males 1
Phentermine Fastin® Appetite suppressant / dieting, weight loss 3
Phentermine Adipex® Appetite suppressant / dieting, weight loss 3
Phenylephrine Neosynephrine® Vasoconstrictor, decongestant / low blood pressure, allergies, sinusitis, asthma 3
Phenylpropanolamine Acutrim® Decongestant / allergies, sinusitis, asthma 3
Phenylpropanolamine Dexatrim® Decongestant / allergies, sinusitis, asthma 3
Pimozide Orap® Anti-psychotic / Tourette's tics Females>Males 1
Procainamide Pronestyl® Anti-arrhythmic / abnormal heart rhythm 1
Procainamide Procan® Anti-arrhythmic / abnormal heart rhythm 1
Protriptyline Vivactil® Tricyclic Antidepressant / depression 4
Pseudoephedrine PediaCare® Decongestant / allergies, sinusitis, asthma 3
Pseudoephedrine Sudafed® Decongestant / allergies, sinusitis, asthma 3
Quetiapine Seroquel® Anti-psychotic / schizophrenia 2
Quinidine Quinaglute® Anti-arrhythmic / abnormal heart rhythm Females>Males 1
Quinidine Cardioquin® Anti-arrhythmic / abnormal heart rhythm Females>Males 1
Ranolazine Ranexa® Anti-anginal / chronic angina 2
Risperidone Risperdal® Anti-psychotic / schizophrenia 2
Ritodrine Yutopar® Uterine relaxant / prevent premature labor 3
Roxithromycin* Rulide® Antibiotic / bacterial infection *not available in the United States 2
Salmeterol Serevent® Sympathomimetic / asthma, COPD 3
Sertraline Zoloft® Anti-depressant / depression 4
Sibutramine Meridia® Appetitie suppressant / dieting, weight loss 3
Solifenacin VESIcare® muscarinic receptor anatagonist / treatment of overactive bladder 4
Sotalol Betapace® Anti-arrhythmic / abnormal heart rhythm Females>Males 1
Sparfloxacin Zagam® Antibiotic / bacterial infection 1
Tacrolimus Prograf® Immunosuppressant / Immune suppression 2
Tamoxifen Nolvadex® Anti-cancer / breast cancer 2
Telithromycin Ketek® Antibiotic / bacterial infection 2
Terbutaline Brethine® Bronchodilator / asthma 3
Thioridazine Mellaril® Anti-psychotic / schizophrenia 1
Tizanidine Zanaflex® Muscle relaxant / 2
Tolterodine Detrol® Bladder Antispasmodic / 3
Tolterodine Detrol LA® Bladder Antispasmodic / 3
Trimethoprim-Sulfa Bactrim® Antibiotic / bacterial infection 4
Trimethoprim-Sulfa Sulfa® Antibiotic / bacterial infection 4
Trimipramine Surmontil® Tricyclic Antidepressant / depression 4
Vardenafil Levitra® phosphodiesterase inhibitor / vasodilator 2
Venlafaxine Effexor® Anti-depressant / depression 2
Voriconazole VFend® Anti-fungal / anti-fungal 2
Ziprasidone Geodon® Anti-psychotic / schizophrenia 2
 
 

Revised: 03/01/2006


Source: www.QTdrugs.org

Drugs on the QT Drug Lists are reviewed on an ongoing basis to assure the evidence is still appropriate for their placement on their respective list. 

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KEY
Drug List 1:
Drugs that are generally accepted by authorities to have a risk of causing torsades de pointes.
Drug List 2:
Drugs that may prolong the QT interval but at this time lack substantial evidence for causing torsades de pointes.
Drug List 3:
Drugs to be avoided for use in patients with diagnosed or suspected congenital long QT syndrome. (Drugs on Lists 1 and 2 are also included here.)
Females>Males:
Substantial evidence indicates a greater risk
(usually > two-fold) of TdP in women.

Arizona Center for Education and Research on Therapeutics
The Critical Path Institute

Tucson, Arizona and Rockville, Maryland

Funded in part by Agency for Healthcare Research and Quality grant 1 U18 HS10385

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Risk Group 2 Risk Group 4 Risk Group 1