Drug List 3


	Drugs to be avoided for use in patients with diagnosed or suspected congenital long QT syndrome. (Drugs on Lists 1, 2, and 4 are also included here.)


Generic Name	Brand Name	Class/Clinical Use	Comments	List
Albuterol	Ventolin®	Bronchodilator / Asthma		3
Albuterol	Proventil®	Bronchodilator / Asthma		3
Alfuzosin	Uroxatral®	Alpha1-blocker / Benign prostatic hyperplasia		2
Amantadine	Symmetrel®	Dopaminergic/Anti-viral / Anti-infective/ Parkinson's Disease		2
Amiodarone	Cordarone®	Anti-arrhythmic / abnormal heart rhythm	Females>Males,TdP risk regarded as low	1
Amiodarone	Pacerone®	Anti-arrhythmic / abnormal heart rhythm	Females>Males,TdP risk regarded as low	1
Amitriptyline	Elavil®	Tricyclic Antidepressant / depression		4
Amoxapine	Asendin®	Tricyclic Antidepressant / depression		4
Amphetamine	Adderall®	CNS stimulant / ADHD	This includes dextroamphetamine and amphetamine / dextroamphetamine combinations.	3
Amphetamine	Dexadrine®	CNS stimulant / ADHD	This includes dextroamphetamine and amphetamine / dextroamphetamine combinations.	3
Arsenic trioxide	Trisenox®	Anti-cancer / Leukemia		1
Atomoxetine	Strattera®	norepinephrine reuptake inhibitor / ADHD		3
Azithromycin	Zithromax®	Antibiotic / bacterial infection		2
Bepridil	Vascor®	Anti-anginal / heart pain	Females>Males	1
Chloral hydrate	Noctec®	Sedative / sedation/ insomnia		2
Chloroquine	Arelan®	Anti-malarial / malaria infection		1
Chlorpromazine	Thorazine®	Anti-psychotic/ Anti-emetic / schizophrenia/ nausea		1
Ciprofloxacin	Cipro®	Antibiotic / bacterial infection		4
Cisapride	Propulsid®	GI stimulant / heartburn	Restricted availability; Females>Males.	1
Citalopram	Celexa®	Anti-depressant / depression		4
Clarithromycin	Biaxin®	Antibiotic / bacterial infection		1
Clomipramine	Anafranil®	Tricyclic Antidepressant / depression		4
Clozapine	Clozaril®	Anti-psychotic / schizophrenia		2
Cocaine	Cocaine	Local anesthetic /		3
Desipramine	Pertofrane®	Tricyclic Antidepressant / depression		4
Dexmethylphenidate	Focalin®	CNS stimulant / ADHD		3
Disopyramide	Norpace®	Anti-arrhythmic / abnormal heart rhythm	Females>Males	1
Dobutamine	Dobutrex®	Catecholamine / heart failure and shock		3
Dofetilide	Tikosyn®	Anti-arrhythmic / abnormal heart rhythm		1
Dolasetron	Anzemet®	Anti-nausea / nausea, vomiting		2
Domperidone*	Motilium®	Anti-nausea / nausea	not available in the United States	1
Dopamine	Intropine®	Anti-arrhythmic / abnormal heart rhythm		3
Doxepin	Sinequan®	Tricyclic Antidepressant / depression		4
Droperidol	Inapsine®	Sedative;Anti-nausea / anesthesia adjunct, nausea		1
Ephedrine	Broncholate®	Bronchodilator, decongestant / Allergies, sinusitis, asthma		3
Ephedrine	Rynatuss®	Bronchodilator, decongestant / Allergies, sinusitis, asthma		3
Epinephrine	Bronkaid®	catecholamine, vasoconstrictor / anaphylaxis, allergic reactions		3
Epinephrine	Primatene®	catecholamine, vasoconstrictor / anaphylaxis, allergic reactions		3
Erythromycin	Erythrocin®	Antibiotic;GI stimulant / bacterial infection; increase GI motility	Females>Males	1
Erythromycin	E.E.S.®	Antibiotic;GI stimulant / bacterial infection; increase GI motility	Females>Males	1
Felbamate	Felbatrol®	Anti-convulsant / seizure		2
Fenfluramine	Pondimin®	Appetite suppressant / dieting, weight loss		3
Flecainide	Tambocor®	Anti-arrhythmic / abnormal heart rhythm		2
Fluconazole	Diflucan®	Anti-fungal / fungal infection		4
Fluoxetine	Prozac®	Anti-depressant / depression		4
Fluoxetine	Sarafem®	Anti-depressant / depression		4
Foscarnet	Foscavir®	Anti-viral / HIV infection		2
Fosphenytoin	Cerebyx®	Anti-convulsant / seizure		2
Galantamine	Reminyl®	Cholinesterase inhibitor / Dementia, Alzheimer's		4
Gatifloxacin	Tequin®	Antibiotic / bacterial infection		2
Gemifloxacin	Factive®	Antibiotic / bacterial infection		2
Granisetron	Kytril®	Anti-nausea / nausea and vomiting		2
Halofantrine	Halfan®	Anti-malarial / malaria infection	Females>Males	1
Haloperidol	Haldol®	Anti-psychotic / schizophrenia, agitation		1
Ibutilide	Corvert®	Anti-arrhythmic / abnormal heart rhythm	Females>Males	1
Imipramine	Norfranil®	Tricyclic Antidepressant / depression		4
Indapamide	Lozol®	Diuretic / stimulate urine & salt loss		2
Isoproterenol	Isupres®	Catecholamine / allergic reaction		3
Isoproterenol	Medihaler-Iso®	Catecholamine / allergic reaction		3
Isradipine	Dynacirc®	Anti-hypertensive / high blood pressure		2
Itraconazole	Sporanox®	Anti-fungal / fungal infection		4
Ketoconazole	Nizoral®	Anti-fungal / fungal infection		4
Levalbuterol	Xopenex®	Bronchodilator / asthma		3
Levofloxacin	Levaquin®	Antibiotic / bacterial infection		2
Levomethadyl	Orlaam®	Opiate agonist / pain control, narcotic dependence		1
Lithium	Eskalith®	Anti-mania / bipolar disorder		2
Lithium	Lithobid®	Anti-mania / bipolar disorder		2
Mesoridazine	Serentil®	Anti-psychotic / schizophrenia		1
Metaproterenol	Alupent®	Bronchodilator / asthma		3
Metaproterenol	Metaprel®	Bronchodilator / asthma		3
Methadone	Dolophine®	Opiate agonist / pain control, narcotic dependence	Females>Males	1
Methadone	Methadose®	Opiate agonist / pain control, narcotic dependence	Females>Males	1
Methylphenidate	Ritalin®	CNS stimulant / ADHD		3
Methylphenidate	Concerta®	CNS stimulant / ADHD		3
Mexiletine	Mexitil®	Anti-arrhythmic / Abnormal heart rhythm		4
Midodrine	ProAmatine®	Vasoconstrictor / low blood pressure, fainting		3
Moexipril/HCTZ	Uniretic®	Anti-hypertensive / high blood pressure		2
Moxifloxacin	Avelox®	Antibiotic / bacterial infection		2
Nicardipine	Cardene®	Anti-hypertensive / high blood pressure		2
Norepinephrine	Levophed®	Vasconstrictor, Inotrope / shock, low blood pressure		3
Nortriptyline	Pamelor®	Tricyclic Antidepressant / depression		4
Octreotide	Sandostatin®	Endocrine / acromegaly, carcinoid diarrhea		2
Ofloxacin	Floxin®	Antibiotic / bacterial infection		2
Ondansetron	Zofran®	Anti-emetic / nausea and vomiting		2
Paroxetine	Paxil®	Anti-depressant / depression		4
Pentamidine	NebuPent®	Anti-infective / pneumocystis pneumonia	Females>Males	1
Pentamidine	Pentam®	Anti-infective / pneumocystis pneumonia	Females>Males	1
Phentermine	Fastin®	Appetite suppressant / dieting, weight loss		3
Phentermine	Adipex®	Appetite suppressant / dieting, weight loss		3
Phenylephrine	Neosynephrine®	Vasoconstrictor, decongestant / low blood pressure, allergies, sinusitis, asthma		3
Phenylpropanolamine	Acutrim®	Decongestant / allergies, sinusitis, asthma		3
Phenylpropanolamine	Dexatrim®	Decongestant / allergies, sinusitis, asthma		3
Pimozide	Orap®	Anti-psychotic / Tourette's tics	Females>Males	1
Procainamide	Pronestyl®	Anti-arrhythmic / abnormal heart rhythm		1
Procainamide	Procan®	Anti-arrhythmic / abnormal heart rhythm		1
Protriptyline	Vivactil®	Tricyclic Antidepressant / depression		4
Pseudoephedrine	PediaCare®	Decongestant / allergies, sinusitis, asthma		3
Pseudoephedrine	Sudafed®	Decongestant / allergies, sinusitis, asthma		3
Quetiapine	Seroquel®	Anti-psychotic / schizophrenia		2
Quinidine	Quinaglute®	Anti-arrhythmic / abnormal heart rhythm	Females>Males	1
Quinidine	Cardioquin®	Anti-arrhythmic / abnormal heart rhythm	Females>Males	1
Ranolazine	Ranexa®	Anti-anginal / chronic angina		2
Risperidone	Risperdal®	Anti-psychotic / schizophrenia		2
Ritodrine	Yutopar®	Uterine relaxant / prevent premature labor		3
Roxithromycin*	Rulide®	Antibiotic / bacterial infection	*not available in the United States	2
Salmeterol	Serevent®	Sympathomimetic / asthma, COPD		3
Sertraline	Zoloft®	Anti-depressant / depression		4
Sibutramine	Meridia®	Appetitie suppressant / dieting, weight loss		3
Solifenacin	VESIcare®	muscarinic receptor anatagonist / treatment of overactive bladder		4
Sotalol	Betapace®	Anti-arrhythmic / abnormal heart rhythm	Females>Males	1
Sparfloxacin	Zagam®	Antibiotic / bacterial infection		1
Tacrolimus	Prograf®	Immunosuppressant / Immune suppression		2
Tamoxifen	Nolvadex®	Anti-cancer / breast cancer		2
Telithromycin	Ketek®	Antibiotic / bacterial infection		2
Terbutaline	Brethine®	Bronchodilator / asthma		3
Thioridazine	Mellaril®	Anti-psychotic / schizophrenia		1
Tizanidine	Zanaflex®	Muscle relaxant /		2
Tolterodine	Detrol®	Bladder Antispasmodic /		3
Tolterodine	Detrol LA®	Bladder Antispasmodic /		3
Trimethoprim-Sulfa	Bactrim®	Antibiotic / bacterial infection		4
Trimethoprim-Sulfa	Sulfa®	Antibiotic / bacterial infection		4
Trimipramine	Surmontil®	Tricyclic Antidepressant / depression		4
Vardenafil	Levitra®	phosphodiesterase inhibitor / vasodilator		2
Venlafaxine	Effexor®	Anti-depressant / depression		2
Voriconazole	VFend®	Anti-fungal / anti-fungal		2
Ziprasidone	Geodon®	Anti-psychotic / schizophrenia		2

Revised: 03/01/2006

Source: www.QTdrugs.org

Drugs on the QT Drug Lists are reviewed on an ongoing basis to assure the evidence is still appropriate for their placement on their respective list.

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KEY
Drug List 1:	Drugs that are generally accepted by authorities to have a risk of causing torsades de pointes.
Drug List 2:	Drugs that may prolong the QT interval but at this time lack substantial evidence for causing torsades de pointes.
Drug List 3:	Drugs to be avoided for use in patients with diagnosed or suspected congenital long QT syndrome. (Drugs on Lists 1 and 2 are also included here.)
Females>Males:	Substantial evidence indicates a greater risk (usually > two-fold) of TdP in women.

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