Drugs that, in some reports, have been weakly associated with Torsades de Pointes and/or QT prolongation but that are unlikely to be a risk for Torsades de Pointes when used in usual recommended dosages and in patients without other risk factors (e.g., concomitant QT prolonging drugs, bradycardia, electrolyte disturbances, congenital long QT syndrome, concomitant drugs that inhibit metabolism).
Amitriptyline Elavil® Tricyclic Antidepressant / depression
Amoxapine Asendin® Tricyclic Antidepressant / depression
Ciprofloxacin Cipro® Antibiotic / bacterial infection
Citalopram Celexa® Anti-depressant / depression
Clomipramine Anafranil® Tricyclic Antidepressant / depression
Desipramine Pertofrane® Tricyclic Antidepressant / depression
Doxepin Sinequan® Tricyclic Antidepressant / depression
Fluconazole Diflucan® Anti-fungal / fungal infection
Fluoxetine Prozac® Anti-depressant / depression
Fluoxetine Sarafem® Anti-depressant / depression
Galantamine Reminyl® Cholinesterase inhibitor / Dementia, Alzheimer's
Imipramine Norfranil® Tricyclic Antidepressant / depression
Itraconazole Sporanox® Anti-fungal / fungal infection
Ketoconazole Nizoral® Anti-fungal / fungal infection
Mexiletine Mexitil® Anti-arrhythmic / Abnormal heart rhythm
Nortriptyline Pamelor® Tricyclic Antidepressant / depression
Paroxetine Paxil® Anti-depressant / depression
Protriptyline Vivactil® Tricyclic Antidepressant / depression
Sertraline Zoloft® Anti-depressant / depression
Solifenacin VESIcare® muscarinic receptor anatagonist / treatment of overactive bladder
Trimethoprim-Sulfa Bactrim® Antibiotic / bacterial infection
Trimethoprim-Sulfa Sulfa® Antibiotic / bacterial infection
Trimipramine Surmontil® Tricyclic Antidepressant / depression
Revised: 12/17/2004

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Arizona Center for Education and Research on Therapeutics
The Critical Path Institute

Tucson, Arizona and Rockville, Maryland

Funded in part by Agency for Healthcare Research and Quality grant 1 U18 HS10385-01

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Risk Group 2 Risk Group 3 Risk Group 1 Risk Group 1 Drug List 2 Risk Group 4