Centers for Education &
Research on Therapeutics™
Monahan BP et al. JAMA 1990;264:2788–2790
Ventricular Arrhythmia (Torsades de Pointes)
 Occurring in Association with Terfenadine Use
§39 y.o. female with 2-day Hx of intermittent syncope §Rx with terfenadine 60 mg bid and cefaclor 250 mg tid ´ 10 d §Self-medicated with ketoconazole 200 mg bid for vaginal candidiasis §Palpitations, syncope, torsades de pointes (QTc 655 msec)