Centers for Education &
Research on Therapeutics™
§Systems interventions
–Electronic prescription entry and bar-coding
–Computerized medication records
–Drug interaction software
§Limitations
–Fragmented healthcare delivery and prescription filling
–Information not uniformly translated into practice
§Message
–Can’t rely completely on technology
–Need basic knowledge of clinical pharmacology
of drug interactions
 Bates DW et al. JAMA 1998;280:1311–1316.  Evans RS et al. Ann Pharmacother 1994;28(4):523–5277 
 Gebhart F. Drug Topics 1999;1:44.  Smalley W et al. JAMA 2000;284(23):3036–3039
Systems Interventions and
Their Limitations