Centers for Education &
Research on Therapeutics™
Aklillu E et al. J Pharmacol Exp Ther 1996;278(1):441– 446
Cytochrome P450 2D6
§Absent in 7% of Caucasians,
 1–2% non-Caucasians
§Hyperactive in up to 30% of East Africans
§Catalyzes primary metabolism of:
–Codeine
–Many b-blockers
–Many tricyclic antidepressants
§Inhibited by:
–Fluoxetine
–Haloperidol
–Paroxetine
–Quinidine